The hormone osteocalcin helps to improve memory in the elderly.
Previously, scientists have found that exercise can release the protein RbAp48, which prevents the development of dementia. In the course of a new study, scientists were able to reveal that RbAp48 controls the level of BDNF and GPR158 – enzymes that are associated with osteocalcin. Experiments on mice showed that RbAp48 is required for the activation of osteocalcin, and thus its positive effects on memory.
According to the researchers, their data suggests that physical activity in old age helps to improve memory in the aging brain. Observation of the mice showed that moderate physical activity, such as walking, allows the release of osteocalcin.
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