The new research into the D614G mutation on the spike protein in SARS-CoV-2, present in all the latest variants currently plaguing healthcare systems the world over, was led by researchers at New York University, the New York Genome Center, and Mount Sinai.
“Confirming that the mutation leads to more transmissibility may help explain, in part, why the virus has spread so rapidly over the past year,” said Neville Sanjana, assistant professor of biology at NYU, who added that the mutation has reached “near universal prevalence” among the coronavirus variants spreading across the globe.
The Mount Sinai researchers injected a virus with the D614G mutation into human lung, liver, and colon cells and compared it against cells from the original strain detected in Wuhan at the start of the pandemic.
They found a whopping eight-fold increase in transmissibility between the two strains, with the mutated spike protein making the virus more resilient to being split by other proteins in the human immune system, highlighting the importance of continued vaccine research and development to combat this hardier version.
“…[O]ur experimental data was pretty unambiguous – the D614G variant infects human cells much more efficiently than the wild type,” said Zharko Daniloski, a postdoctoral fellow in Sanjana’s lab at NYU and the study’s co-first author.
Thankfully, however, the mutation has not yet been linked to more intense progression of Covid-19 leading to more severe forms of the disease or an increase in hospitalization.
On the other hand, this does pose another issue: the current generation of vaccines were developed based on the original Wuhan-variant spike protein structure, highlighting the need for booster vaccines or even annual vaccination programs to halt the spread of the coronavirus for good.
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