The researchers were able to increase the number of ON cells in free-living nematodes.
Scientists of the Federal Polytechnic school of Lausanne (Switzerland) found a way to increase the content in the cells of nicotinamide adenine dinucleotide (NAD), which is believed to increase the lifetime of the organism.
OVER – the coenzyme required for many enzymatic functions and is involved in maintaining the cell alive. It is shown that with age the content in the cells decreases, which, according to scientists associated with the aging process.
The researchers were able to increase the number of ON cells in free-living nematodes Caenorhabditis elegans and mice with inhibitors of the enzyme ACMSD, which limits the synthesis of nicotinamide adenine dinucleotide. It turned out that this activates a connecting sirtuin-1, dependent ON and involved in the functioning of the mitochondria.
In addition, scientists have shown that inhibitors of ACMSD improve the functioning of organs in animals suffering from acute renal failure and non-alcoholic fatty liver disease. That ACMSD is present exclusively in the liver and kidneys eliminates a major negative impact from blocking his drugs on other organs.
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