Scientists want to make antibiotic treatment more effective.
Scientists from Aarhus University in Denmark found that bacteria are able to resist the effects of antibiotics, there are “palindromes” embedded in the amino acid sequence of some proteins. The impact on them will make the microorganisms more vulnerable to treatment. Their findings the researchers presented in a paper published in the journal Nucleic Acids Research.
In order to survive the action of antibiotics or the immune system, germs are able to enter the hibernation state. One of the key components of this mechanism — the release of toxins produced by the bacteria that inhibit the growth and development of microorganisms. However, under normal conditions, to subscribe toxins antitoxins that turn them off, thus making the bacterium active.
Scientists have found that antitoxins are present in the palindromic sequence of amino acids. In other words, they are the same when read left to right or right to left. Palindromes help the protein to change its configuration so that to deactivate from two molecules of toxin. Analysis of more than four thousand genomes of microorganisms have shown that palindromes are used in about a fourth of all known bacteria.
The researchers hope that their findings will help to create a new class of drugs that affect the palindromes in such a way as to prevent the release of toxins. This will make antibiotic treatment more effective.
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