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Found a genetic mutation that leads to obesity

Найдена генетическая мутация, приводящая к ожирению Scientists have come to unexpected conclusions.

Scientists from the Baltic Federal University. Immanuel Kant (BFU) and Tomsk national research medical center has taken an important step in the study of the metabolic syndrome, identifying a number of defining polymorphisms (gene mutations).

Metabolic syndrome is a complex of disorders, manifested in obesity and high blood pressure. It increases the risk of cardiovascular disease and diabetes, and often fatal consequences.

“Study of molecular mechanisms of metabolic syndrome is particularly important because of its prevalence and rising incidence of obesity”, – said the head of the laboratory of immunology and cell biotechnologies Immanuel Kant Baltic Federal University Larisa Litvinova.

The authors of the article in the “International Journal of Obesity” (journal of the publishing house “the Nature”) studied as metabolic syndrome is affected by genetics, comparing groups of healthy people and patients with schizophrenia since the syndrome is found significantly more often.

Attracted the attention of scientists the NOS3 gene responsible for the synthesis of nitrogen in the body. The fact that patients with metabolic syndrome, its production is disturbed, making it impossible for normal work of blood vessels.

“We found the relationship between the polymorphism – substitution level of the nucleotide chain T-786C in NOS3 and indicators of metabolic syndrome: high blood glucose and blood pressure, concentration of cholesterol and triglycerides in the blood,” – said Larisa Litvinova.

According to her, the polymorphism T-786C determined by the regulation of cholesterol levels. Moreover, for patients with schizophrenia it plays a special “protective” role by neutralizing the damaging molecular substances due to the increased synthesis of plasma nitrite.

In addition to the T-786C, scientists have described two other NOS3 polymorphisms that increase the risk of metabolic disorders in healthy people. They stress the importance of further research for the “victory” over the metabolic syndrome using genetic engineering.

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