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Discovered the secret of invulnerability fungi

Раскрыт секрет неуязвимости грибков“Superpowers” acquire and pathogenic fungi.

Genetics from MSU and sechenovskiy University have discovered why many disease-causing fungi become immune to the action of new drugs. Their findings were presented in the journal Scientific Reports.

In recent years, professionals are more and more it becomes a problem of occurrence of so-called “superbugs” — germs resistant to one or more antibiotics. Among them are rare pathogens and very common and dangerous pathogens, such as Staphylococcus aureus or Streptococcus pneumoniae.

In addition to the microbes, similar to the “superpowers” and become pathogenic fungi, starting with scab pathogens and Candida and ending with ergot and other fungi, which are parasitic on plants and cause damage to agriculture. Unlike microbes, neutralizing molecules of antibiotics, fungi are merely “milking” venom from their cells back into the environment before it is something you have time to do.

Dmitry Knorre, a biologist from Moscow state University named after M. V. Lomonosov and his colleagues for several years trying to create drugs that could resist the action of such systems “self-cleaning”.

Two years ago, as it seemed to the Russian researchers, they were able to solve this problem by downloading their pump meaningless work and “hiding” toxic substances inside the mitochondria of fungi isolated parts of the cell, playing the role of their “stations”.

The work of these substances Knorre and his colleagues tested on cultures of normal Baker’s yeast (Saccharomyces cerevisiae) that is resistant to many conventional antifungal drugs. These experiments unexpectedly showed that the fungi lost stability to the effects of drugs — about two hours later, they felt a “deception” and began to deflate and molecules,”dummy”, and the poison back to the nutrient medium.

The reason for this, as discovered genetics, was the change in activity of several genes PDR1, PDR5 and other DNA regions, presumably associated with the operation of cellular pumps. How they “know” that in the mitochondria of the fungus are present in the molecules of the poison, scientists still don’t understand, but plan to find out soon.

These experiences, according to biologists, will be held harmless yeast, but also on pathogenic fungi such as Candida albicans. Their results, as I hope the authors will help to protect crops from mildew and rot, and the human body from uninvited “guests”.

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